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General Information

Job Name
Staff Research Associate
Department
1384010 - M Med Core Pulm
Position type
Full Time
Workplace
Fully On-Site
Primary Location
San Francisco, CA, United States
Job ID
540

Description & Requirements

Job Description

JOB SUMMARY

The incumbent in this position will independently execute research in the Upadhyay Laboratory investigating how gut bacterial metabolites regulate lung epithelial mitochondrial function during acute respiratory distress syndrome (ARDS). Building on published findings that Bifidobacterium adolescentis-derived L-lactate increases mitochondrial activity in lung epithelial cells and correlates with ARDS severity (Upadhyay et al., bioRxiv 2025Nat Cell Biol), the SRA 2 will work under general supervision to advance a mechanistic understanding of the gut-lung axis in critical illness. The SRA 2 is expected to bring demonstrated laboratory proficiency, execute experiments with independence, troubleshoot problems before escalating to the PI, and contribute to data analysis and scientific communication.

This position will be working under the general supervision of Dr. Vaibhav Upadhyay at the Upadhyay Laboratory, Benioff Center for Microbiome Medicine and Division of Pulmonary and Critical Care Medicine, UCSF Parnassus campus.

 

 

Qualifications
Required Qualifications - BS/BA degree in biology, biochemistry, molecular biology, or related field and one or more years of recent, directly related work experience utilizing the techniques or methods required by the position; and/or equivalent experience/training. - Ability to work independently, prioritize multiple tasks, and troubleshoot problems before escalating to supervisor. - Experience in microbiology, metabolic assays, mouse handling, or bioinformatics preferred. - Computer skills at the level of using spreadsheet programs - Prior experience in a respiratory, microbiome, or metabolism-focused laboratory is a plus. - Experience with image analysis software and basic statistics (GraphPad Prism or equivalent). - Experience handling mice - Familiarity with gnotobiotic mouse models or other specialized in vivo systems preferred - Experience with metabolic assays (Seahorse XF respirometry, lactate quantification) - anesthesia, ear tagging, intratracheal and peritoneal injections, and euthanasia. - Computer skills at the level of using spreadsheet programs - Strong written and verbal communication skills for lab meeting presentations and figure preparation. Preferred Qualifications - Demonstrated proficiency in mammalian cell culture: independent maintenance, passaging, and troubleshooting of cell lines. - Demonstrated proficiency in molecular biology techniques: RNA isolation, qPCR, western blotting. - Experience with bacterial culture, including anaerobic techniques, preferred.
About UCSF
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.
Pride Values
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as https://www.ucsf.edu/about/mission-and-values . In addition to , UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available https://diversity.ucsf.edu/ . Join us to find a rewarding career contributing to improving healthcare worldwide.
EEO Statement
The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

Additional Details

Job Code
SRA 2 NEX (009617)
Assignment Category
Career
IAP Level
None
Job Family
Research and Laboratory
Campus 1
Parnassus Heights (SF)
Percentage (%)
100
Shift Length
8 hours
Shift Type
Day
Bargaining Unit
RX
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